Chicken Scampi Stuffed Pasta Shells Recipe

This Chicken Scampi Stuffed Pasta Shells recipe transforms classic garlic butter scampi into a crowd-pleasing, cheesy pasta bake. Jumbo pasta shells are stuffed with seasoned chicken and cheese, then smothered in a rich, garlicky white wine sauce that will have everyone asking for seconds. It’s surprisingly simple to make but delivers restaurant-quality flavors right at your dinner table!

Ingredients You’ll Need

• Jumbo Pasta Shells: These create the perfect vessels for holding all that delicious chicken and cheese filling.
• Chicken Tenders: Diced into bite-sized pieces, they cook quickly and stay tender inside the shells.
• Cheese Blend: A combination of monterey jack, cheddar, and mozzarella creates the perfect melty, gooey texture while adding layers of flavor.
• Spice Blend: Paprika, cayenne, garlic powder, onion powder, oregano, salt, and pepper create a flavor-packed coating for the chicken.
• Butter: The foundation of any good scampi sauce, providing richness and helping to carry all those delicious flavors.
• Garlic: Fresh minced garlic is non-negotiable here – it’s the heart and soul of scampi sauce.
• White Wine: Use something you’d actually drink! The wine adds acidity and complexity to the sauce.
• Chicken Stock: Adds depth to the sauce without making it too heavy.
• Heavy Cream: Creates that luxurious, silky texture that clings perfectly to the pasta.
• Lemon: Both zest and juice brighten the entire dish and cut through the richness.
• Fresh Parsley: Adds a pop of color and fresh flavor that brings everything together.

Variations

Seafood Twist

Replace the chicken with shrimp or a combination of seafood for a more traditional scampi approach.

Veggie Boost

Mix in sautéed spinach, mushrooms, or artichoke hearts to the chicken filling for extra nutrients and flavor.

Cheese Variations

Try different cheese combinations – fontina, gruyere, or even a touch of goat cheese can add interesting flavor dimensions.

Gluten-Free Option

Use gluten-free jumbo shells and ensure your chicken stock and other ingredients are certified gluten-free.

How to Make Chicken Scampi Stuffed Pasta Shells

Step 1: Prepare the Chicken

Mix your chicken seasoning blend together, reserving 1 teaspoon for the sauce. Toss diced chicken with olive oil and the remaining seasoning mixture until evenly coated. Heat olive oil in a large pan over medium-high heat, cook the chicken until it reaches 165°F internal temperature. Transfer to a bowl and tent with foil.

Step 2: Cook the Pasta

Bring a large pot of salted water to a boil and cook the jumbo shells to al dente according to package directions. Remember they’ll cook more in the oven, so don’t overdo it. Reserve 1/3 cup of pasta water before draining.

Step 3: Make the Scampi Sauce

In the same pan you cooked the chicken, melt 2 tablespoons of butter over medium heat. Add minced garlic and sauté until fragrant, about 2 minutes. Pour in the white wine and let it reduce for about 5 minutes. Whisk in the remaining butter, red pepper flakes, reserved seasoning, chicken stock, lemon zest and juice, heavy cream, parmesan, and parsley. Simmer until slightly thickened, then add the pasta water to reach your desired consistency.

Step 4: Stuff and Assemble

Mix the cooked chicken with half of your shredded cheese. Spread 1/2 cup of sauce on the bottom of a greased 9×13 baking dish. Stuff each pasta shell with a generous spoonful of the chicken-cheese mixture and arrange them in the dish. Pour the remaining sauce over the shells, making sure each one gets some love.

Step 5: Bake to Perfection

Top everything with the remaining cheese and bake at 375°F for 15-20 minutes until the cheese is beautifully melted and bubbly.

How to Serve

Main Course Star

Serve these stuffed shells as your main dish with a simple side salad dressed with lemon vinaigrette to complement the flavors.

Side Pairings

A side of garlic bread is perfect for soaking up extra sauce, while roasted asparagus or broccoli adds a nice green element to balance the richness.

Wine Pairing

The same dry white wine you used in the sauce makes an excellent pairing. A crisp Pinot Grigio or Sauvignon Blanc works beautifully.

Make Ahead and Storage

Make Ahead

Prepare everything up to the baking step, cover tightly with plastic wrap, and refrigerate for up to 24 hours. When ready to eat, simply bake as directed, adding 5-10 minutes to the cooking time if coming straight from the refrigerator.

Storing Leftovers

Store any leftovers in an airtight container in the refrigerator for up to 3 days. The flavors actually continue to develop, making the leftovers incredibly delicious.

Freezing

You can freeze the assembled but unbaked dish for up to 1 month. Wrap tightly with plastic wrap and then aluminum foil. Thaw in the refrigerator overnight before baking.

Reheating

The best way to reheat is in a 350°F oven, covered with foil for about 20 minutes until heated through. You can also microwave individual portions, though the texture won’t be quite as good.

FAQs

This Chicken Scampi Stuffed Pasta Shells recipe brings together the best of comfort food and elegant dining. The contrast between the al dente pasta, tender seasoned chicken, and that velvety, garlicky sauce creates something truly special. It’s become a family favorite in my house, and I’m constantly asked to make it for gatherings with friends. Even if you’re not usually confident in the kitchen, this recipe breaks down into simple steps that anyone can master. Give it a try – I promise your kitchen will smell amazing and your taste buds will thank you!

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